intTypePromotion=1
zunia.vn Tuyển sinh 2024 dành cho Gen-Z zunia.vn zunia.vn
ADSENSE

Báo cáo Y học: Determinants of antagonist binding at the a-amino-3-hydroxy5-methyl-4-isoxazolepropionic acid receptor subunit, GluR-D Role of the conserved arginine 507 and glutamate 727 residues

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:10

39
lượt xem
3
download
 
  Download Vui lòng tải xuống để xem tài liệu đầy đủ

Previous structural andmutagenesis studies indicate that the invariant a-amino and a-carboxyl groups of glutamate receptor agonists are engaged in polar interactions with oppositely charged, conserved arginine and glutamate resi-dues in the ligand-binding domain ofa-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor.To examine the role of these residues (R507 and E727 in the GluR-D subunit) in the discrimination between agonists and anta-gonists, we analyzed the ligand-binding properties of homomeric GluR-D and its soluble ligand-binding domain withmutations at thesepositions....

Chủ đề:
Lưu

Nội dung Text: Báo cáo Y học: Determinants of antagonist binding at the a-amino-3-hydroxy5-methyl-4-isoxazolepropionic acid receptor subunit, GluR-D Role of the conserved arginine 507 and glutamate 727 residues

ADSENSE

CÓ THỂ BẠN MUỐN DOWNLOAD

 

Đồng bộ tài khoản
23=>2