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Báo cáo Y học: Expanding the scorpion toxin a-KTX 15 family with AmmTX3 from Androctonus mauretanicus
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Anovel toxin,AmmTX3 (3823.5 Da), was isolated fromthe venomof the scorpionAndroctonusmauretanicus. It showed 94% sequence homology with Aa1 fromAndroctonus aus-tralis and 91% with BmTX3 fromButhus martensiwhich, respectively,blockA-typeK + current incerebellumgranular cells and striatum cultured neurons. Binding and displace-ment experiments using rat brain synaptosomes showed that AmmTX3 and Aa1 competed effectively with 125 I-labelled sBmTX3 binding.
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