Báo cáo Y học: The evolution of monomeric and oligomeric bc-type crystallins
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The case of homologous monomeric c-type and oligomeric b-type crystallins has been described and analyzed in evolutionary terms. Data and hypotheses from molecular genetics and structural investigations converge and suggest a novel three-phase model for the evolutionary history of crystallin-type proteins. In the divergent cascades of monomeric and oligomeric crystallins, a pivotal role was played by alterations in the gene segments encoding the C-terminal extensions and the intermotif or interdomain linker peptides. These were genomic hot spots where evolution experimented to produce the modern variety of bc-crystallin-type quaternary structures. Keywords: crystallins; evolution; quaternary structure; introns late; introns early. ...
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