Clinical and genomic features in patients with second primary glioblastoma following first primary renal cell carcinoma

To explore the potential pathogenesis and clinical features of second primary glioblastoma (spGBM) follow‑ ing first primary renal cell carcinoma (fpRCC). Patients with spGBM after fpRCC were enrolled from our institution and the SEER dataset. Sanger sequencing, whole genome sequencing, and immunohistochemistry were used to detect molecular biomarkers.