Clinicopathological and mutational characteristics of primary double mutant gastrointestinal stromal tumor: A single center study with review of the literature

Primary double KIT/PDGFRA mutations are very rare in gastrointestinal stromal tumours (GISTs) but have not been comprehensively studied to date. In the present study, we investigated the clinicopathologic and genetic features of eight cases of primary double-mutant GISTs, and we reviewed the literature.