Cobalt induces alterations in serum parameters associated with bone metabolism in male adult rat

The intention of this study was to investigate the toxic effect of cobalt on the bone metabolism of rats, including calcium, inorganic phosphorus, and bone-specific alkaline phosphatase of serum during short- and long-term experiments. Rats were injected intraperitoneally (IP) with either 16 mg kg–1 BW of cobalt for 5 and 10 days or 6 mg kg–1 BW for 20 and 40 days.