Injected intraperitoneally
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Saroglitazar is a novel PPAR-α/γ agonist with predominant PPAR-α activity. In various preclinical models, saroglitazar has been shown to prevent & reverse symptoms of NASH. In view of these observations, and the fact that NASH is a progressive disease leading to HCC, we hypothesized that saroglitazar may prevent the development of HCC in rodents.
13p vileonardodavinci 23-12-2023 6 2 Download
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N-acetylcysteine amide (NACA) is a new antioxidant molecule with powerful radical scavenging properties. The aim of this study was to investigate neuroprotective effects of NACA against paraquat (PQ) toxicity in the midbrains of rats by using motor coordination tests and biochemical and histological analysis. Thirty adult Wistar albino rats were divided into three groups: Group 1: control (n = 10), Group 2: PQ (10 mg/kg) (n = 10), and Group 3: PQ (10 mg/kg) + NACA (100 mg/kg) (n = 10). NACA was administrated intraperitoneally 30 min before PQ injection.
11p tudichquannguyet 29-11-2021 6 1 Download
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Tapinanthus dodoneifolius (Loranthaceae) is an epiphytic parasitic plant used in the treatment of cholera, asthma, hypertension, and diabetes. The general objective of this study was to evaluate the antidiabetic properties of the aqueous extract of the leaves of T. dodoneifolius (Loranthaceae) in the Wistar rat. Type 1 diabetes was induced by intraperitoneal injection of streptozotocin into the single dose of 60 mg/kg.
13p chauchaungayxua12 29-07-2021 11 1 Download
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The aim of this study was to determine the pathogenicity of koi ranavirus (KIRV) in common carp (Cyprinus carpio L) and rohu (Labeo rohita H). In the present study, common carp and rohu fingerlings were experimentally infected with KIRV by intraperitoneal injection with 50 µl of the virus preparation having an infectious dose of 106.9 TCID50/ml.
10p caygaocaolon11 21-04-2021 7 1 Download
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To investigate the effects and potential mechanism of L161982 (a kind of EP4 antagonist) on the collagen-induced arthritis (CIA) mice model. The CIA mice model were first established by immunizing with Chicken Type II Collagen on DBA/1 mice. The CIA groups were administered once a day for 2 weeks with either 5 mg/kg L161982 by intraperitoneal injections (IP), 200 U celecoxib by intragastrical injections, or 100 μl PBS (IP).
8p vitennessee2711 02-02-2021 15 1 Download
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This study was carried out to evaluate the effect of fenugreek plant on CCL4 –induced liver injury by following the hematological and biochemical parameters. To achieve this purpose forty male albino rats were used and divided to four groups. The first group represented control group which received normal diet and intraperitoneal injection with oil (0.5ml/kg). The second group represented the CCL (1ml/kg) model. The third group received 200 mg/kg fenugreek leaves extract by gavage.
10p angicungduoc6 20-07-2020 10 1 Download
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Dung beetle glycosaminoglycan is known to possess anti-aging activities. However, its anti-cancer mechanisms are not fully elucidated yet. The objective of this study was to evaluate the anti-cancer effect of insectderived polymer dung beetle glycosaminoglycan (GAG) after intraperitoneally injecting it to melanoma mice induced by B16F10 cells.
12p viputrajaya2711 22-06-2020 10 0 Download
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Toxoplasma gondii infection has a worldwide distribution. Pyrimethamine (PYR) is the most effective drug for treatment of toxoplasmosis. Unfortunately, it has low oral bioavailability which requires an increase in the dose that results in increased its side effects. Nanostructures showed promising potential to overcome this problem. This study aimed to evaluate the effect of intraperitoneal injection (IP) of PYR-loaded niosomes compared to PYR in the treatment of acute toxoplasmosis in experimentally infected mice.
20p nguaconbaynhay4 22-03-2020 14 2 Download
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The present study aimed to investigate the mode of action of nano-CaPs in vivo as a therapy for solid tumor in mice. To achieve this goal, Ehrlich Ascites Carcinoma (EAC) was transplanted into 85 Swiss male albino mice. After nine days, the mice were divided into 9 groups. Groups 1 and 2 were allocated as the EAC control. Groups 3 and 4 were injected once intratumorally (IT) by nano-calcium phosphate (nano-CaP). Groups 5 and 6 received once intraperitoneal injection (IP) of nano-CaP. Groups 7, 8, and 9 received nano-CaP (IP) weekly.
12p kequaidan1 16-11-2019 22 1 Download
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Given the self nature of cancer, anti-tumor immune response is weak. As such, acute inflammation induced by microbial products can induce signals that result in initiation of an inflammatory cascade that helps activation of immune cells. We aimed to compare the nature and magnitude of acute inflammation induced by toll-like receptor ligands (TLRLs) on the tumor growth and the associated inflammatory immune responses. To induce acute inflammation in tumor-bearing host, CD1 mice were inoculated with intraperitoneal (i.p.
11p kequaidan1 16-11-2019 16 1 Download
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The intention of this study was to investigate the toxic effect of cobalt on the bone metabolism of rats, including calcium, inorganic phosphorus, and bone-specific alkaline phosphatase of serum during short- and long-term experiments. Rats were injected intraperitoneally (IP) with either 16 mg kg–1 BW of cobalt for 5 and 10 days or 6 mg kg–1 BW for 20 and 40 days.
7p caplock2711 22-02-2019 36 0 Download
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To investigate the hypoglycemic action of CF2 in a type 2-like diabetic mice model induced by high fat diet (HFD) combined with streptozotocin (STZ) injection. Method: Model: mice were fed with HFD for 8 weeks, then injected with a dose of STZ (100 mg/kg body weight, intraperitoneal injection). Animal used: Swiss male mice. Drugs: type 2-like diabetic mice with HFD and STZ treated with either gliclazide 80 mg/kg body weight.
8p cumeo4000 01-08-2018 23 0 Download
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We report the isolation of a novel antimicrobial peptide, bass hepcidin, from the gill of hybrid striped bass, white bass (Morone chrysops) · striped bass (M. saxatilis). After the intraperitoneal injection of Micrococcus luteus and Escherichia coli, the peptide was purified from HPLC fractions with antimicrobial activity against Escherichia coli. Sequencing by Edman degradation revealed a 21-residue peptide (GCRFCCNCCPNMSGCGVCCRF) with eight putative cysteines.
6p research12 01-06-2013 28 3 Download
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Intraperitoneal injection of choline (30–90 mgÆkg )1 ) produced a dose-dependent increase in serum insulin, glu-cose and choline levels in rats.The increase in serum insulin induced by choline (90 mgÆkg )1 ) was blocked by pretreat-mentwith themuscarinic acetylcholine receptor antagonists, atropine (2 mgÆkg )1 ), pirenzepine (2 mgÆkg )1 ) and 4-diphe-nylacetoxy-N-methylpiperidine (2 mgÆkg )1 ) or the gangli-onic nicotinic receptor antagonist, hexamethonium (15 mgÆkg )1 ).
9p tumor12 20-04-2013 43 2 Download
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To evaluate the immune activation and reactive oxygen species scavenging activity of Cordyceps militaris polysaccharides (CMP) in vivo, 90 male BALB/c mice were randomly divided into six groups. The mice in the three experimental groups were given cyclophosphamide at 80 mg/kg/d via intraperitoneal injection and 17.5, 35, or 70 mg/kg body weight CMP via gavage. The lymphocyte proliferation, phagocytic index, and biochemical parameters were measured.
6p the_eye_1991 18-09-2012 108 17 Download