Comparative study on retention behaviour and enantioresolution of basic and neutral structurally unrelated compounds with cellulose-based chiral stationary phases in reversed phase liquid chromatography-mass spectrometry conditions

In this paper, a comparative study on the retention behaviour and enantioresolution of 54 structurally unrelated neutral and basic compounds using five commercial cellulose-based CSPs and mixtures consisting of organic solvent (methanol or acetonitrile) and 5 mM ammonium bicarbonate (pH = 8.0) in varying proportion as MS-compatible mobile phases is performed.