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Consomic mouse strain selection based on effect size measurement, statistical significance testing and integrated behavioral z-scoring: Focus on anxietyrelated behavior and locomotion
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Selecting chromosome substitution strains (CSSs, also called consomic strains/lines) used in the search for quantitative trait loci (QTLs) consistently requires the identification of the respective phenotypic trait of interest and is simply based on a significant difference between a consomic and host strain. However, statistical significance as represented by P values does not necessarily predicate practical importance.
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