Crimean–congo haemorrhagic fever (CCHF): A zoonoses

The viral RNA dependent RNA polymerase (L protein) binds to a promoter on each encapsidated segment, and transcribes the mRNA. The virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell. Transcription is terminated by a strong hairpin sequence at the end of each gene, and the transcripts are capped by L protein during synthesis using cap snatching process in the cytoplasm.