Cultured human periosteum derived cells can differentiate into osteoblasts in a perioxisome proliferator activated receptor gamma mediated fashion via bone morphogenetic protein signaling

The differentiation of mesenchymal stem cells towards an osteoblastic fate depends on numerous signaling pathways, including activation of bone morphogenetic protein (BMP) signaling components. Commitment to osteogenesis is associated with activation of osteoblast-related signal transduction, whereas inactivation of this signal transduction favors adipogenesis.