Dihomo-γ-linolenic acid inhibits xenograft tumor growth in mice bearing shRNAtransfected HCA-7 cells targeting delta-5- desaturase

We previously demonstrated that knockdown of delta-5-desaturase via siRNA transfection together with dihomo-γ-linolenic acid supplementation inhibited colon cancer cell growth and migration, by promoting the production of the anti-cancer byproduct 8-hydroxyoctanoic acid from Cyclooxygenase-2-catalyzed dihomo-γ-linolenic acid peroxidation.