Dynamic interactions between cephalexin and macrophages on different Staphylococcus aureus inoculum sizes: A tripartite in vitro model

The bactericidal activity of an antimicrobial drug is generally assessed by in vitro bacterial time-kill experiments which do not include any components of the immune system, even though the innate immunity, the primary host defence, is probably able to kill a large proportion of pathogenic bacteria in immunocompetent patients.