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Minimum inhibitory concentration
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Resistance to pathogenic bacteria may lead to serious health problems. Scientists found that discovering novel antimicrobial compounds is possible by exploring rarely investigated environments. Therefore, this work focused on isolating and identifying some fungal strains collected from the Co To sea. We tested whether such strains can produce compounds with vital activities, including antibacterial and antifungal. The antimicrobial activity of the marine fungi crude extracts was performed by the Bioassay method in a 96-well tray.
10p
dianmotminh02
03-05-2024
3
1
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Part 1 book "Drug therapy for infectious diseases of the dog and cat" includes content: Understanding minimum inhibitory concentrations, static versus cidal antibiotics, in vitro versus in vivo efficacy, why antibiotics fail, safe writing skills, basic math skills, central nervous system infections,,... and other contents.
160p
oursky04
14-09-2023
4
2
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Bài viết trình bày xác định tỷ lệ đề kháng kháng sinh nhóm Beta- lactam và Quinolone của vi khuẩn Enterobacteriaceae; tỷ lệ đề kháng Colistin của chủng vi khuẩn Pseudomonas aeruginosa; Xác định Minimum Inhibitory Concentration (MIC) của Colistin bằng phương pháp Broth disk elution trên vi khuẩn Enterobacteriaceae đề kháng Beta- lactam và Quinolone; vi khuẩn Pseudomonas aeruginosa đề kháng Colistin trên máy kháng sinh đồ tự động.
7p
visybill
19-07-2023
5
2
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The sea is a unique ecosystem for finding secondary metabolites from marine microorganisms. Many compounds produced by marine microorganisms with antibacterial activity have been applied in life. Furthermore, microorganisms are renewable raw materials and media for drug production, thus crucial for sustainable development in our life.
10p
vicaptainmarvel
21-04-2023
6
3
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This study aims to provide an in vitro evidence for the potential antibacterial activity of the ethanolic and aqueous extracts from fruiting bodies of the Pycnoporus sanguineus (L.: Fr.) Murrill mushroom via agar well diffusion method (concentration of extracts 250 mg/mL) and determination of the antibacterial activity and minimum inhibitory concentrations (MIC) of ethanolic and aqueous extracts from the fruiting bodies of this mushroom by agar dilution method (concentration range of 25; 12.5; 6.25; 3.125 and 1.5625 mg/mL).
8p
viporsche
28-10-2022
6
2
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Sevoflurane potently enhances glycine receptor currents and more modestly decreases NMDA receptor currents, each of which may contribute to immobility. This modest NMDA receptor antagonism by sevoflurane at a minimum alveolar concentration (MAC) could be reciprocally related to large potentiation of other inhibitory ion channels.
7p
viisaacnewton
26-04-2022
12
1
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The bactericidal activity of an antimicrobial drug is generally assessed by in vitro bacterial time-kill experiments which do not include any components of the immune system, even though the innate immunity, the primary host defence, is probably able to kill a large proportion of pathogenic bacteria in immunocompetent patients.
10p
vidarwin
23-02-2022
15
1
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Apramycin is used exclusively for the treatment of Escherichia coli (E.coli) infections in swine around the world since the early 1980s. Recently, many research papers have demonstrated that apramycin has significant in vitro activity against multidrug-resistant E.coli isolated in hospitals.
8p
vigandhi
23-02-2022
12
1
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In the past decade, Mycoplasma synoviae (M. synoviae) infection has become widely prevalent in China, has caused serious economic losses and has become one of the most important diseases in the chicken industry.
8p
vidarwin
22-02-2022
13
1
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Nghiên cứu này xác định thành phần hóa học chính, nồng độ ức chế tối thiểu vi khuẩn phân lập (Minimum Inhibitory Concentration - MIC), nồng độ diệt khuẩn tối thiểu (Minimum Bactericidal Concentration - MBC), và nồng độ diệt nấm tối thiểu (Minimum Fungicidal Concentration - MFC) của tinh dầu 4 loài trong chi Ocimum, họ Hoa Môi (Lamiaceae): é trắng (Etr), húng quế (HQ), hương nhu trắng (HNTr) và hương nhu tía (HNT).
6p
vihassoplattner
04-01-2022
39
0
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The investigated bacteria found to have a strong ability to form biofilms with densities ranged from 0.67 to 0.80. Both tested extracts inhibited these biofilms with percentages ranged from 48 to 66% at sub-inhibitory concentrations (SICs) ranged from 0.04 to 0.16 mg/mL.
9p
schindler
30-12-2021
12
0
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Inhibitory effect of oil and its preparations were studied using disc-diffusion and Minimum Inhibitory Concentration (MIC) tests, and using corn oil and Streptomycin as controls.
6p
schindler
30-12-2021
14
0
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A series of binucleating Cu(II), Ni(II), and Zn(II) complexes of bicompartmental ligands with ONO donors were prepared. The ligands were synthesized by the condensation of 5-substituted-3-phenyl-1H -indole-2-carboxyhydrazides and 4,6-diacetylresorcinol. The newly synthesized ligands and their complexes were characterized by elemental analysis and various spectral studies like IR, 1H NMR, ESI-mass, UV-Vis, ESR, thermal studies, magnetic susceptibility, molar conductance, and powder-XRD data.
21p
langthannam
29-12-2021
8
0
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The newly synthesized compounds were screened for their antimicrobial activities; some of them were found to be active towards the test microorganisms as the results demonstrated that the synthesized compounds exhibited a broad spectrum of activity with minimum inhibitory concentration (MIC) values of 31.3–500 µg/mL against gram-positive and gram-negative bacteria, Candia albicans and Saccharomyces cerevisiae.
12p
langthannam
29-12-2021
8
0
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This study was the first fatty acid analysis and biological activity report on an endemic Achillea species, Achillea cappadocica Hausskn. et Bornm. The major compounds in the fatty acid were identified as oleic (34.7%), palmitic (23.1%), and linoleic acids (20.6%). The methanol and water extracts indicated higher ABTS cation radical scavenging activity than that of α-tocopherol and BHT at 100 µg/mL. The acetone extract showed 70.62% inhibitory activity against butyrylcholinesterase at 200 µg/mL. The acetone and methanol extracts exhibited moderate antimicrobial activity.
8p
langthannam
29-12-2021
17
0
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The new compounds 7a–k, 8a–k, and 9a–k were synthesized from flavonones 4–6, which can be considered new precursors for quinoline synthesis through a one-step reaction. All the target compounds (7a–k, 8a–k, and 9a–k) were evaluated for their in vitro antimicrobial activity against nine test microorganisms. They showed the most activity against Mycobacterium smegmatis with minimum inhibitory concentrations (MIC) of 62.5–500 µg/mL, indicating their potential uses as antituberculosis agents. Among them 8a–k (m-fluoride) were the most active compounds against M. smegmatis (MIC, 62.5–125 µg/mL).
17p
langthannam
29-12-2021
11
0
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The aim of this study was to evaluate the antimicrobial activity of three commercial GSE (Grapefruit Seed Extract) products against six bacterial and one fungal strain, through the agar well diffusion method, determination of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungicidal concentration (MFC). Obtained results indicate strong antimicrobial effects of investigated extracts, with different microbial susceptibility, including the multidrug-resistant (MDR) bacteria.
4p
mudbound
10-12-2021
11
1
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A series of 3-mercapto-1,2,4-triazole–pyrrole hybrids was designed as antimycobacterial agents by employing 5- (4-(1H -pyrrol-1-yl)phenyl)-4H -1,2,4-triazole-3-thiol as the scaffold onto which several types of moieties were introduced in the triazole ring at N-4 and N-2 and as substituents of the mercapto function. The aforementioned moieties are an allyl or a phenyl moiety at N-4; an aminomethyl group at N-2; or methyl, substituted benzyl, ethoxycarbonylmethyl, or substituted phenacyl at sulfur.
16p
tudichquannguyet
29-11-2021
8
1
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The absolute configuration of compound 14 was found as SR in the solid state. Analytical and spectroscopic data of the phosphazenes were consistent with their suggested structures. Antimicrobial activities of the benzyl-pendant-armed cyclotriphosphazenes were scrutinized against G(+) and G(−) bacteria and yeast strains. The bacterium most affected by the synthesized compounds was Pseudomonas aeruginosa. Minimum inhibitory concentrations and minimal bacterial concentrations were in the range of 125–500 µM.
26p
tudichquannguyet
29-11-2021
9
1
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In the present work, a library of fifteen 2-hydroxy benzothiazole-linked 1,3,4 -oxadiazole derivatives have been synthesized and confirmed using different analytical techniques. All of the synthesized compounds have been tested for antibacterial and in silico pharmacokinetic studies for the first time. From the ADME predictions, compound 4 showed the highest in silico absorption percentage (86.77%), while most of the compounds showed more than 70% absorption.
22p
tudichquannguyet
29-11-2021
5
1
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