Efficacy and safety of duloxetine for postoperative pain after total knee arthroplasty in centrally sensitized patients: Study protocol for a randomized controlled trial

Postoperative residual knee pain after total knee arthroplasty (TKA) is a significant factor that contributes to patient dissatisfaction. Patients with preoperative central sensitization (CS) may be more susceptible to unexplained chronic pain after TKA, and duloxetine has been reported to be effective in post-TKA pain control in patients with CS.