Efficacy of oral isotretinoin in combination with levocetirizine in management of severe acne vulgaris

To evaluate the outcomes of the treatment of severe acne vulgaris by combining oral isotretinoin and levocetirizine; controlled comparative clinical trial. 60 patients with severe acne vulgaris were randomly divided into 2 groups: 30 patients in treated group were managed with oral isotretinoin 0,3 - 0.5mg/kg/ day and levocetirizine 5mg/day and 30 patients in control group were managed with oral isotretinoin 0,3 - 0.5mg/kg/day only. Assessment was made at baseline, after 3, 4, 8 and 12 weeks.