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Efficacy of tyrosine kinase inhibitors in patients with non-small-cell lung cancer with performance status 4: A case series and review of the literature
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Current guidelines for non-small-cell lung cancer (NSCLC) recommend that each tyrosine kinase inhibitor (TKI) is indicated even for driver mutation-positive patients with a poor performance status (PS). In previous studies, most patients had a PS of 2–3, but those with a PS of 4 were very few. Therefore, the efcacy of TKIs in patients with NSCLC with a PS of 4 remains unclear.
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