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Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patients
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Colibactin, a genotoxin produced by polyketide synthase harboring (pks+) bacteria, induces doublestrand breaks and chromosome aberrations. Consequently, enrichment of pks+Escherichia coli in colorectal cancer and polyposis suggests a possible carcinogenic effect in the large intestine.
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