Evaluation of subchronic toxicity of Tri Thien Duoc hard capsule in experimental animals

The rats were treated with the doses of 0.566 g extract/kg per day and 1.698 g extract/kg per day for a period of 90 consecutive days. Tri Thien Duoc hard capsule caused no significant dose-related changes in general status, hematological parameters, renal and hepatic function tests; in addition, it did not cause any change in histology of the liver and kidney of the rats. Our finding obtained that the Tri Thien Duoc hard capsule did not cause subchronic toxicity in experimental animals.