Heparin - Pluronic F127 nanogel with optimal component ratio for drug delivery applications

This study aimed to synthesize a nanogel system based on Heparin (Hep) and Pluronic F127 (F127) copolymers with optimal Hep:F127 ratio for delivering poor water soluble drug and Platinum-based drugs. Firstly, Hep-F127 conjugates were formed via disulfide bridges of cystamine molecules.