Hepatoprotective effects of phenolic glycosides from the methanol extract of physalis angulata

By various chromatographic separations, four phenolic glycosides, methyl salicylate 2-Otriglycoside (1), icariside E5 (2), quercetin 3-O-rutinoside (3), and isorhamnetin 3-O-rutinoside (4) were isolated from the methanol extract of the whole plant of Physalis angulata. Their structures were determined by 1D-, 2D-NMR spectroscopic analyses and by comparison with reported data. Compounds 3 exhibited significant hepatoprotective activity with an EC50 value of 17.08 µg/mL. This is the first report of 1-4 from Physalis angulata.