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Hi-C as a tool for precise detection and characterisation of chromosomal rearrangements and copy number variation in human tumours
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Chromosomal rearrangements occur constitutionally in the general population and somatically in the majority of cancers. Detection of balanced rearrangements, such as reciprocal translocations and inversions, is troublesome, which is particularly detrimental in oncology where rearrangements play diagnostic and prognostic roles.
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