High tumor hexokinase-2 expression promotes a pro-tumorigenic immune microenvironment by modulating CD8+/ regulatory T-cell infiltration

Relationship between cancer cell glycolysis and the landscape of tumor immune microenvironment in human cancers was investigated. Forty-one fresh lung adenocarcinoma (ADC) tissues were analyzed using flow cytometry for comprehensive immunoprotein. Formalin-fixed tissues were immunostained for hexokinase-2 (HK2) to assess cancer cell glycolysis.