HRE finder: A tool for quarrying hypoxia-response element in genomic sequences

During hypoxia, the hypoxia inducible factor (HIF) binds to hypoxiaresponse elements (HRE) and induces the expression of hypoxia-inducible genes (HIG). A functionally active HRE typically contains an adjacent hypoxia ancillary sequence (HAS) in its downstream within the space of 7- 15 nt.