Influence of Casein kinase II inhibitor CX4945 on BCL6-mediated apoptotic signaling in B-ALL in vitro and in vivo

Casein kinase II (CK2) is involved in multiple tumor-relevant signaling pathways affecting proliferation and apoptosis. CK2 is frequently upregulated in acute B-lymphoblastic leukemia (B-ALL) and can be targeted by the ATP-competitive CK2 inhibitor CX-4945.