Ketamine exacerbates cortical neuroapoptosis under hyperoxic conditions by upregulating expression of the Nmethyl-D-aspartate receptor subunit NR1 in the developing rat brain

Ketamine and hyperoxia are widely used in obstetric and pediatric settings. Either ketamine or hyperoxia has been reported to cause neuroapoptosis in the developing brain, and ketamine-induced neuronal apoptosis may involve a compensatory upregulation of the N-methyl-D-aspartate (NMDA) receptor NR1 subunit. T