Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genomewide forward genetic screen in human colorectal cancer cells

The Ras pathway genes KRAS, BRAF, or ERBBs have somatic mutations in ~ 60% of human colorectal carcinomas. At present, it is unknown whether the remaining cases lack mutations activating the Ras pathway or whether they have acquired mutations in genes hitherto unknown to belong to the pathway.