LncRNA AFAP1-as functions as a competing endogenous RNA to regulate RAP1B expression by sponging miR-181a in the HSCR

Long noncoding RNAs (lncRNAs) have recently emerged as important regulators in a broad spectrum of cellular processes including development and disease. Despite the known engagement of the AFAP1-AS in several human diseases, its biological function in Hirschsprung disease (HSCR) remains elusive.