Nanoparticle formulation of rosuvastatin: Enhancing solubility and clinical potential

This study outlines a nanotechnology-based method to enhance its solubility and absorption of rosuvastatin. The process entails the formulation of rosuvastatin nanoparticles through a combination of precipitation and ultrasonic techniques. Rosuvastatin is initially dissolved in an organic solvent, such as acetone, and subsequently mixed with an aqueous phase containing stabilizers like Poloxamer 407 or PVP to induce precipitation. Ultrasound reduces particle size to 50-200 nm.