Clinical potential
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In recent years, there has been extensive research on the role of exercise as an adjunctive therapy for cancer. However, the potential mechanisms underlying the anti-tumor therapy of exercise in lung cancer remain to be fully elucidated. As such, our study aims to confirm whether exercise-induced elevation of epinephrine can accelerate CD8+ T cell recruitment through modulation of chemokines and thus ultimately inhibit tumor progression.
16p vishanshan 27-06-2024 2 1 Download
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Whole-mount histopathology (WMH) has been a powerful tool to investigate the characteristics of prostate cancer. However, the latest advancement of WMH was yet under summarization. In this review, we offer a comprehensive exposition of current research utilizing WMH in diagnosing and treating prostate cancer (PCa), and summarize the clinical advantages of WMH and outlines potential on future prospects.
13p vishanshan 27-06-2024 2 1 Download
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This study aimed to identify new pyroptosis-associated tumor antigens for use in mRNA vaccines and the screening of sensitive LUAD populations suitable for vaccination. The association between tumor immune infiltrating cell abundance and potential tumor antigens was investigated and visualized using the analysis modules of gene expression, clinical outcomes, and somatic copy number variation.
15p vishanshan 27-06-2024 2 1 Download
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This systematic review and meta-analysis aimed to determine the potential value of neutrophil to lymphocyte ratio (NLR) as an assessment tool in the clinical distinction between uterine sarcoma and uterine leiomyoma.
9p vishanshan 27-06-2024 1 1 Download
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Deprescribing is a clinical intervention aimed at managing polypharmacy and improving older adults’ health outcomes. However, evidence suggests that healthcare professionals (HCPs) may face challenges in implementing the intervention. This study aimed to explore the considerations, barriers and enablers of deprescribing among HCPs in Southwest Nigeria.
11p vishanshan 27-06-2024 1 1 Download
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The study emphasizes the importance of telehealth SLP services in meeting the increasing demand for mental health interventions among children and adolescents. It suggests integrating telehealth into clinical practice beyond the pandemic and highlights the need for long-term evaluation and addressing potential barriers to access.
8p vishanshan 27-06-2024 2 1 Download
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Breast cancer (BrCa) is a predominant malignancy, with metastasis occurring in one in eight patients, nearly half of which target the bone, leading to serious complications such as pain, fractures, and compromised mobility. This study aims to assess the efficacy of CTRA in monitoring osteolytic lesions’ progression and response to therapy, suggesting its potential superiority over existing methodologies in guiding treatment strategies.
13p vishanshan 27-06-2024 1 1 Download
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This article aims to explore novel insights into the pathophysiology of different epithelial ovarian carcinoma groups, with implications for potential screening and intervention methods in the future.
5p vikoch 27-06-2024 3 1 Download
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Despite the existence of numerous studies investigating the diagnostic potential of blood microRNAs for colorectal cancer, the microRNAs under consideration vary widely, and comparative analysis of their diagnostic value is lacking. Consequently, this systematic review aims to identify the most effective microRNA blood tumor markers to enhance clinical decision-making in colorectal cancer screening.
15p vikoch 27-06-2024 1 1 Download
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Accumulating evidence indicates that the use of antibiotics (ATBs) in cancer patients is potentially correlated with patient prognosis. Interestingly, the use of these agents is not uncommon in colorectal cancer (CRC) patients during surgery; however, their prognostic value in the clinic has never been addressed.
11p vikoch 27-06-2024 2 1 Download
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The objective of this study is to investigate the correlation between CD27 expression and the prognosis of MM, and to elucidate its potential relationship with the immune microenvironment.
13p vikoch 27-06-2024 1 1 Download
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Despite the utilization of immune checkpoint inhibitors (ICIs) in treating numerous types of cancers being approved, their efficacy in tumor control in the clinic is not satisfactory. Since adoptive cell therapy (ACT) can alter the tumor microenvironment, we hypothesized that ACT potentially synergized with ICI in tumor control and examined this hypothesis via a murine allograft model.
11p vikoch 27-06-2024 1 1 Download
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This study aimed to identify metabolic subtypes in ESCA, explore their relationship with immune land‑ scapes, and establish a metabolic index for accurate prognosis assessment. Methods Clinical, SNP, and RNA-seq data were collected from 80 ESCA patients from the TCGA database and RNAseq data from the GSE19417 dataset. Metabolic genes associated with overall survival (OS) and progression-free survival (PFS) were selected, and k-means clustering was performed.
16p vikoch 27-06-2024 1 1 Download
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Recently, propolis has shown potential cardioprotective effects against myocardial infarction. However, challenges in its clinical application have arisen, primarily due to concerns regarding dosage and potential adverse effects. To address this, we suggest integrating propolis into polyvinyl alcohol (PVA)/gelatin hydrogel to regulate the localized release of propolis at infarcted sites.
7p visergeyne 18-06-2024 0 0 Download
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The book also describes what cerebral monitoring can do and what its limitations are. In addition, proper selection of the available monitoring devices, set-up procedures, the technique of electrode placement, trouble shooting and data interpretation are fully covered. Various typical cases underline how EEG power spectra and evoked potential changes are interpreted, how they are used in the light of other variables being measured how they can serve to get a deeper insight into the underlying clinical situation.
183p vimeyers 29-05-2024 4 2 Download
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Ebook "Lymphangiogenesis in cancer metastasis" covers all aspects of this new field from the fundamental role that protein growth factors and their receptors play in lymphangiogenesis to the potential application of these advances to cancer diagnosis and treatment. Other clinical aspects explored include the mechanisms and importance of lymph node metastasis, the role of the lymphatics in lymphangioleiomyomatosis and Kaposi’s sarcoma, and approaches for imaging lymphatics in cancer.
254p dongmelo 27-05-2024 6 2 Download
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In this study, two derivatives of hydrazineylidene-3-oxopropanal: chlorophenyl (CPHO) and Nitrophenyl (NPHO) substituted hydrazineylidene compounds were synthesized, spectroscopically characterized using (FT-IR, UV, and NMR), and theoretically modelled as a potential drug for the treatment of antiviral hepatitis (HBV and HCV) using insillico molecular docking approach.
17p dianmotminh02 03-05-2024 3 1 Download
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This book provides a resource for better understanding of surgical procedures and potential complications in general terms. The application of this material will depend on the individual patient and clinical context. Part 1 book "Cardio thoracic, vascular, renal and transplant surgery" includes content: Introduction; blood transfusion; arterial surgery; venous surgery; amputation surgery.
103p zizaybay1101 30-04-2024 2 2 Download
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Prelabor rupture of membranes (PROM) remains a challenge in obstetrics with serious complications. Quantitative vaginal fluid creatinine concentration is a promising test for diagnosing PROM in resource-limiting settings. However, uncovered factors may affect the diagnostic power of this potential test. We aimed to investigate how clinical factors may affect this diagnostic power.
10p viohoyo 25-04-2024 1 1 Download
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Ebook "Complement therapeutics" highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis.
323p ladongphongthanh1008 22-04-2024 3 3 Download