Clinical potential

This study outlines a nanotechnology-based method to enhance its solubility and absorption of rosuvastatin. The process entails the formulation of rosuvastatin nanoparticles through a combination of precipitation and ultrasonic techniques. Rosuvastatin is initially dissolved in an organic solvent, such as acetone, and subsequently mixed with an aqueous phase containing stabilizers like Poloxamer 407 or PVP to induce precipitation. Ultrasound reduces particle size to 50-200 nm.

10p tuongmotranh 18-03-2025 1 1   Download

Brachytherapy is a form of radiotherapy in which radioactive sources are placed at short distances from, or even inside the target volume. The use of high dose rate brachytherapy is a widely accepted and clinically proven treatment for some stages of prostate cancer. The aim of this project was to investigate potential improvements on two of the most important aspects of high dose rate (HDR) and pulsed dose rate (PDR) prostate brachytherapy - prostate definition and treatment delivery verification.

121p runthenight05 01-03-2023 13 3   Download

The aim of this study was to investigate the potential impact of obesity on patients’ clinical outcome and response to the usual post orthopaedic surgery thromboprophylaxis enoxaparin or aspirin. Additionally, the participants perceived barrier(s) to adherence to the prescribed prophylaxis were explored.

224p runthenight04 02-02-2023 4 2   Download

To describe histopathological and immunoshistochemical characteristics of recurrent, metastatic differentiated thyroid carcinoma. To determine the prevalence of BRAF V600E mutation, and investigate potential association between BRAF V600E mutation and some histopathological and clinical characteristics.

27p angicungduoc6 21-07-2020 25 2   Download

To assess the clinical significance of electrophysiological, functional, and morphometric studies of the optic nerve in patients with serous meningitis during the recovery period.

8p lucastanguyen 01-06-2020 21 3   Download

Biotherapeutics (BTs), one of the fastest growing classes of drug molecules, offer several advantages over the traditional small molecule pharmaceuticals because of their relatively high specificity, low off-target effects, and biocompatible metabolism, in addition to legal and logistic advantages. However, their clinical utility is limited, among other things, by their high immunogenic potential and/or variable therapeutic efficacy in different patient populations.

7p caothientrangnguyen 09-05-2020 27 1   Download

Medium-chain acyl-CoA dehydrogenase (MCAD) is a homotetrameric flavoprotein which catalyses the initial step of theb-oxidationofmedium-chain fattyacids.Mutations in MCAD may cause disease in humans. A Y42H mutation is frequently found in babies identified by newborn screening with MS/MS, yet there are no reports of patients presenting clinically with this mutation. As a basis for judging its potential consequences we have examined the protein phe-notype of the Y42H mutation and the common disease-associatedK304E mutation. ...

11p awards 05-04-2013 44 4   Download

Onconase, a member of the ribonuclease superfamily, is a potent cytotoxicagent that isundergoingphase II/IIIhuman clinical trials as an antitumor drug. Native onconase from Rana pipiensand its amphibian homologs have an N-ter-minal pyroglutamyl residue that is essential for obtaining fully active enzymes with their full potential as cytotoxins. When expressed cytosolically in bacteria, Onconase is isolated with an additional methionyl (Met1) residue and glutaminyl insteadof a pyroglutamyl residue at position 1 of the N-terminus and is consequently inactivated....

9p dell39 03-04-2013 34 4   Download

Cyclic nucleotide specific phosphodiesterases (PDEs) are important components of all cAMP signalling networks. In humans, 11 different PDE families have been identified to date, all of which belong to the class I PDEs. Pharmaco-logically, theyhavebecome of great interest as targets for the development of drugs for a large variety of clinical condi-tions. PDEs in parasitic protozoa have not yet been exten-sively investigated, despite their potential as antiparasitic drug targets.

11p dell39 03-04-2013 42 4   Download

Cystine-knot miniproteins are members of a large family of small proteins that are defined by a common structural scaffold which is stabilized by three intramolecular disulfide bonds. Cystine-knot miniproteins display a broad spectrum of therapeutically useful natural biological activities and several family members are marketed as therapeutics or are in clinical development.

7p galaxyss3 07-03-2013 32 4   Download

Characterization of the peptide content of venoms has a number of poten-tial benefits for basic research, clinical diagnosis, development of new therapeutic agents, and production of antiserum. Here, we use a substrate-capture assay that employs a catalytically inactive mutant of thimet oligo-peptidase (EC 3.4.24.15; EP24.15) to identify novel bioactive peptides in Bothrops jararacussu venom.

13p media19 06-03-2013 47 5   Download

Heterozygous loss-of-function mutations at the glucosecerebrosidase locus have recently been shown to be a potent risk factor for Lewy body disease. Based on this observation, we have re-evaluated the likelihood that the dif-ferent PARK loci (defined using clinical criteria for disease) may be misleading attempts to find common pathways to pathogenesis.

7p vinaphone15 28-02-2013 52 3   Download

Because clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain’s own endogenous strategies for neuroprotection. Two endogenous mechanisms have been characterized so far, namely ischemic preconditioning and ische-mic postconditioning.

12p vinaphone15 27-02-2013 33 2   Download

The increasing number of chromosomal rearrangements involving the humanMLLgene, in combination with differences in clinical behavior and outcome for MLL-rearranged leukemia patients, makes it necessary to reflect on the cancer mechanism and to discuss potential therapeutic strate-gies. To date, 64 different translocations have been identified at the molecular level.

10p mobifone23 21-01-2013 58 4   Download

Previous studies have suggested that microRNAs (miRNAs) may play important roles in tumorigenesis, but little is known about the functions of most miRNAs in cancer development. In the present study, we set up a cell-based screen using a luciferase reporter plasmid carrying the whole 4.7 kb 3¢-UTR of estrogen receptor a(ERa) mRNA cotransfected with a synthetic miRNA expression library to identify potential ERa-targeting miRNAs.

11p mobifone23 18-01-2013 63 4   Download

Colorectal cancer (CRC) is a major public health issue worldwide, and novel tumor markers may contribute to its efficient management by helping in early detection, prognosis or surveillance of disease. The aim of our study was to identify new serum biomarkers for CRC, and we followed a phased biomarker discovery and validation process to obtain an accurate preliminary assessment of potential clinical utility.

15p cosis54 08-12-2012 52 2   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Intra-oral orthosis vs amitriptyline in chronic tension-type headache: a clinical and laser evoked potentials study

9p panasonic05 22-12-2011 56 5   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:The clinical potential of microRNAs

7p toshiba24 06-12-2011 68 5   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: The L76V mutation in HIV-1 protease is potentially associated with hypersusceptibility to protease inhibitors Atazanavir and Saquinavir: is there a clinical advantage?

9p toshiba23 18-11-2011 47 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Clinical review: Emergency department overcrowding and the potential impact on the critically ill...

5p thulanh17 23-10-2011 58 5   Download