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Báo cáo khoa học: An estrogen receptor a suppressor, microRNA-22, is downregulated in estrogen receptor a-positive human breast cancer cell lines and clinical samples

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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Previous studies have suggested that microRNAs (miRNAs) may play important roles in tumorigenesis, but little is known about the functions of most miRNAs in cancer development. In the present study, we set up a cell-based screen using a luciferase reporter plasmid carrying the whole 4.7 kb 3¢-UTR of estrogen receptor a(ERa) mRNA cotransfected with a synthetic miRNA expression library to identify potential ERa-targeting miRNAs.

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Nội dung Text: Báo cáo khoa học: An estrogen receptor a suppressor, microRNA-22, is downregulated in estrogen receptor a-positive human breast cancer cell lines and clinical samples

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