New potentiometric sensors for methylphenidate detection based on host–guest interaction

The study aims to develop simple, sensitive, and selective methods for detecting methylphenidate in its bulk, dosage form and human urine. Sensing materials include β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD), and 4-tertbutylcalix[8] arene as ionophores or electroactive materials have been used for construction of sensors 1, 2, and 3, respectively.