Nghiên cứu quy trình tổng hơp Howiinol A

 4. J. S. Brimacombe and L.C. N. Tuker - Reaction of D-glycero-D-glulo-heptono-y-Iactone<br /> with acetone, Carbohydrate Research 2 (1966) 341-348.<br /> 5. Tonny K. M. Shing, Hon-chung Tsui, Zhao-hui Zhou ~nd Thomas C. W. Mak -<br /> Stereose1ective - syntheses od 2,4:5,6-Di-O-isopropylidene-I-C-phenyl-D-glycero-D-ido-<br /> hexitol and 2,4:5,6-Di-O-isopropylidene-I-C-phenyl-D-glycero-D-gulo-hexitol from D-<br /> glycero-D-gulo-heptono-y-Iactone. X-ray Structure of I-O-Acetyl-2,4: 5,6-Di-O-<br /> isopropylidene-I-C-phenyl-D-glycero-D-ido-hexitol, J. Chern. Soc. Perkin Trans 1 (1992)<br /> 887-893.<br /> 6. Masayoshi Tsubuki, Kazuo Kanai, Hiromasa Nagase, and Toshio Honda -<br /> Stereocontrolled Syntheses of Novel Styryl Lactones, (+)-Goniodiol, (+)-Goniotriol, (+)-<br /> 8-Acetylgoniotriol, (+)-Goniofufurone, (+)-9-Deoxygoniopypyrone, (+)-Gonipypyrone,<br /> and (+)-Altholactone from Common Intermediates and Cytotoxicity of Their congeners,<br /> Tetrahedron 55 (1999) 2493-2514.<br /> 7. Tonny K. M. Shing and Vicint W-F. Tai - Facile and Enantiospecific Syntheses of<br /> Goniotriol Analogues, J. Org. Chern 64 (1999) 2140-2144.<br /> <br /> SUMMARY<br /> <br /> STUDY ON THE SYNTHESIS OF HOWIINOL A<br /> The antitumor compound howiinol A has been isolated and characterized for the first time<br /> from the root and stem bark of Goniothalamus howii Merr. (Annonaceae). This compound<br /> blocked the cell cycle transition from G 1 phase to S phase and inhibited the activity of<br /> topoisomerase II both inside and out side the cells. The methode of howiinol synthesis has been<br /> studied by the scientists of lnstitute of Materia Medica Beijiing in 1998. Herein, we describe<br /> another methode for the synthesis of howiinol A. The structure of howiinol and intermediate<br /> products were estabilished by MS and NMR spectroscopies.<br /> <br /> <br /> Dia chi: Nh(in hili ngay 15 tJuing 2 niim 2008<br /> Vi~n H6a hQc, Vi~n KH&CNVN.<br /> <br /> <br /> <br /> <br /> 89<br />