Nuclear factor-kappaB regulates the transcription of NADPH oxidase 1 in human alveolar epithelial cells

Acute lung injury (ALI) is characterized by infammation and oxidative stress. Nuclear factor-kappaB (NF-κB) mediates the expression of various infammation-related genes, including the NADPH oxidase family. This study aimed to identify the potential regulatory role of NF-κB on NADPH oxidases in tumor necrosis factor-α (TNF-α)- induced oxidative stress in human alveolar epithelial cells.