Patient and provider perspectives on polygenic risk scores: Implications for clinical reporting and utilization

Polygenic risk scores (PRS), which ofer information about genomic risk for common diseases, have been proposed for clinical implementation. The ways in which PRS information may infuence a patient’s health trajectory depend on how both the patient and their primary care provider (PCP) interpret and act on PRS information. We aimed to probe patient and PCP responses to PRS clinical reporting choices.