Potential wMUS81 inhibitory activity of triterpenoids isolated from Helicteres hirsuta and Pterospermum truncatolobatum: A molecular docking studies

The winged-helix domain within the N-terminus of human MUS81 has been considered as potential target for drug development since the inhibition of this protein might significantly enhance the sensitivity of various cancer cells towards anticancer drugs. Nine cytotoxic triterpenoids previously purified from Helicteres hirsuta and Pterospermum truncatolobatum were selected for the docking experiment.