Preoperative chemoradiation with paclitaxel-carboplatin or with fluorouraciloxaliplatin—folinic acid (FOLFOX) for resectable esophageal and junctional cancer: The PROTECT-1402, randomized phase 2 trial

Often curative treatment for locally advanced resectable esophageal or gastro-esophageal junctional cancer consists of concurrent neoadjuvant radiotherapy and chemotherapy followed by surgery. Currently, one of the most commonly used chemotherapy regimens in this setting is a combination of a fluoropyrimidin and of a platinum analogue.