Promoting physical activity through supervised vs motivational behavior change interventions in breast cancer survivors on aromatase inhibitors (PAC-WOMAN): Protocol for a 3-arm pragmatic randomized controlled trial

Aromatase inhibitors (AI) are frequently used to treat hormone-receptor-positive breast cancer, but they have multiple adverse effects (e.g., osteoporosis, arthralgia), resulting in premature therapy discontinuation/ switch. Physical activity (PA) can attenuate these negative effects and improve quality of life (QoL).