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Propofol versus placebo (with rescue with ketamine) before less invasive surfactant administration: Study protocol for a multicenter, double-blind, placebo controlled trial (PROLISA)
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One major limitation for less invasive surfactant administration (LISA) is the difficulty in providing sedation before this procedure and the competitive risk of respiratory depression versus avoidance of intubation for most sedative or analgesic drugs used in this context.
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