Research on the preparation of amlodipine 5mg immediate release film coated tablets to improve active ingredient’s stability

Amlodipine is a representative active ingredient of calcium channel blockers. In addition to the general advantages of calcium channel blockers in treating hypertension, amlodipine also effectively controls blood pressure for 24 hours and has no or just a little effect on neurohormonal activation, so it does not cause high blood pressure at the last dose. However, amlodipine has a plasma half-life of between 30 and 40 hours, slowing the drug's action duration.