Revealing the developmental origin and lineage predilection of neural progenitors within human bone marrow via single-cell analysis: Implications for regenerative medicine

Human bone marrow stromal cells (BMSCs) are an easily accessible and expandable progenitor population with the capacity to generate neural cell types in addition to mesoderm. Lineage tracing studies in transgenic animals have indicated Nestin+BMSCs to be descended from the truncal neural crest.