Risk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: A large-scale association study of East Asian and European populations

The genetic architectures of colorectal cancer are distinct across diferent populations. To date, the majority of polygenic risk scores (PRSs) are derived from European (EUR) populations, which limits their accurate extrapolation to other populations. Here, we aimed to generate a PRS by incorporating East Asian (EAS) and EUR ancestry groups and validate its utility for colorectal cancer risk assessment among diferent populations.