The importance of macroprolactin in the diagnosis of hyperprolactinemia

This article provides a brief review of macroprolactin (MPRL) – what, why, how, and when. Prolactin (PRL) secretion is uniquely controlled by tonic dopamine inhibition. Circulating PRL is a heterogeneous mixture of different sized proteins – monomer, dimer, and a large PRLimmunoglobulin aggregate also known as MPRL.