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3D chromosome structure
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Numerous genome-wide association studies (GWAS) conducted to date revealed genetic variants associated with various diseases, including breast and prostate cancers. Despite the availability of these large-scale data, relatively few variants have been functionally characterized, mainly because the majority of single-nucleotide polymorphisms (SNPs) map to the non-coding regions of the human genome.
18p
vihagrid
30-01-2023
9
3
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We report SPIN, an integrative computational method to reveal genome-wide intranuclear chromosome positioning and nuclear compartmentalization relative to multiple nuclear structures, which are pivotal for modulating genome function.
23p
viarchimedes
26-01-2022
8
0
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The 3D organization of the chromatin fiber in cell nuclei plays a key role in the regulation of gene expression. Genome-wide techniques to score DNADNA contacts, such as Hi-C, reveal the partitioning of chromosomes into epigenetically defined active and repressed compartments and smaller “topologically associated” domains.
20p
viarchimedes
26-01-2022
7
0
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The development of chromosomal conformation capture techniques, particularly, the Hi-C technique, has made the analysis and study of the spatial conformation of a genome an important topic in bioinformatics and computational biology. Aided by high-throughput next generation sequencing techniques, the Hi-C technique can generate genome-wide, large-scale intra- and inter-chromosomal interaction data capable of describing in details the spatial interactions within a genome.
17p
vibeauty
23-10-2021
9
0
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Deciphering the 3D structure of the genome is essential for elucidating the regulatory mechanisms of gene expression in detail. Existing methods, such as chromosome conformation capture (3C) and Hi-C have enabled the identification of novel aspects of chromatin structure.
6p
visilicon2711
20-08-2021
16
1
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More and more 3C/Hi-C experiments on prokaryotes have been published. However, most of the published modeling tools for chromosome 3D structures are targeting at eukaryotes. How to transform prokaryotic experimental chromosome interaction data into spatial structure models is an important task and in great need.
10p
visilicon2711
20-08-2021
5
1
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Recent advances in genome analysis have established that chromatin has preferred 3D conformations, which bring distant loci into contact. Identifying these contacts is important for us to understand possible interactions between these loci.
13p
visilicon2711
20-08-2021
23
1
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Three-dimensional spatial organization of chromosomes is defined by highly self-interacting regions 0.1–1 Mb in size termed Topological Associating Domains (TADs). Genetic factors that explain dynamic variation in TAD structure are not understood. We hypothesize that common structural variation (SV) in the human population can disrupt regulatory sequences and thereby influence TAD formation.
10p
vijeeni2711
24-07-2021
16
0
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Meiotic recombination between homologous chromosomes provides natural combinations of genetic variations and is a main driving force of evolution. It is initiated via programmed DNA double-strand breaks (DSB) and involves a specific axial chromosomal structure.
14p
vikentucky2711
26-11-2020
11
1
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The knowledge of the spatial organisation of the chromatin fibre in cell nuclei helps researchers to understand the nuclear machinery that regulates DNA activity. Recent experimental techniques of the type Chromosome Conformation Capture (3C, or similar) provide high-resolution, high-throughput data consisting in the number of times any possible pair of DNA fragments is found to be in contact, in a certain population of cells.
11p
vikentucky2711
24-11-2020
5
1
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Assays that are capable of detecting genome-wide chromatin interactions have produced massive amount of data and led to great understanding of the chromosomal three-dimensional (3D) structure. As technology becomes more sophisticated, higher-and-higher resolution data are being produced, going from the initial 1 Megabases (Mb) resolution to the current 10 Kilobases (Kb) or even 1 Kb resolution.
13p
vioklahoma2711
19-11-2020
6
1
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Chromatin 3D conformation plays important roles in regulating gene or protein functions. High-throughout chromosome conformation capture (3C)-based technologies, such as Hi-C, have been exploited to acquire the contact frequencies among genomic loci at genome-scale.
17p
vicolorado2711
22-10-2020
11
1
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Alterations in chromatin packing are not the only physical manifestations of cancer. A cluster of tumour cells will also usually display gross structural changes that pathologists use for diagnosis: cells look visibly deformed and are often enlarged, with swollen and misshapen nuclei; and the chromosomes are distri- buted eccentrically. In an attempt to study these chan- ges more accurately, researchers at ASU’s Biodesign Institute have developed an optical computerized tomography (CT) scan for individual cells.
7p
taisaokhongthedung
09-01-2013
38
4
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The 3D structure of methanogen chromosomal protein 1 (MC1), deter-mined with heteronuclear NMR methods, agrees with its function in terms of the shape and nature of the binding surface, whereas the 3D structure determined with homonuclear NMR does not.
13p
mobifone23
08-01-2013
41
3
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Recovery and Visualization of 3D Structure of Chromosomes from Tomographic Reconstruction Images
13p
dauphong20
10-03-2012
46
5
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