Active site profiling

Lytic polysaccharide monooxygenases (LPMOs) play a key role in enzymatic conversion of plant cell wall polysaccharides. Continuous discovery and functional characterization of LPMOs highly contribute to the tailormade design and improvement of hydrolytic-activity based enzyme cocktails.

10p viginny 30-12-2022 13 2   Download

We investigated rupture geometry, size, and slip distribution of October 30, 2020, Samos (Sisam)–Kuşadası earthquake combining seismographs, GPS measurements, and SAR analysis. Right after the earthquake, we measured 13 additional campaignbased GPS sites to intensify the available GPS network consisting of 10 continuous stations. We combined all available seismographs to have the best possible accuracy for mainshock and aftershock hypocenter locations. We compiled all available seismic profiles and integrated them using high-resolution bathymetry to map seismically active faults.

11p tanmocphong 29-01-2022 13 1   Download

Current peak callers for identifying RNA-binding protein (RBP) binding sites from CLIP-seq data take into account genomic read profiles, but they ignore the underlying transcript information, that is information regarding splicing events. So far, there are no studies available that closer observe this issue.

8p vijeeni2711 30-06-2021 14 1   Download

Chromatin immunoprecipitation combined with high-throughput sequencing (ChIP-Seq) is the most frequently used method to identify the binding sites of transcription factors. Active binding sites can be seen as peaks in enrichment profiles when the sequencing reads are mapped to a reference genome.

11p viwyoming2711 16-12-2020 11 1   Download

Development of automatable processes for clustering proteins into functionally relevant groups is a critical hurdle as an increasing number of sequences are deposited into databases. Experimental function determination is exceptionally time-consuming and can’t keep pace with the identification of protein sequences.

13p vioklahoma2711 19-11-2020 19 1   Download

Ureases are enzymes that hydrolyze urea into ammonium and carbon dioxide. They have received considerable attention due to their impacts on living organism health, since the urease activity in microorganisms, particularly in bacteria, are potential causes and/or factors contributing to the persistence of some pathogen infections. This review compiles examples of the most potent antiurease organic substances. Emphasis was given to systematic screening studies on the inhibitory activity of rationally designed series of compounds with the corresponding SAR considerations.

32p trinhthamhodang1 14-11-2019 24 1   Download

A social network service is an online service, platform, or site that focuses on building and reflecting of social networks or social relations among people, e.g., who share interests and/or activities. A social network service essentially consists of a representation of each user (often a profile), his/her social links, and a variety of additional services. Most social network services are web based and provide means for users to interact over the internet, such as e-mail and instant messaging.

49p thamgiacongdong 02-05-2013 54 7   Download

While 23% said social media did give them some ability to monitor what was being said, only 9% said that the ability to measure the frequency of discussion about the organization was a current benefit and only 18% said they were able to identify positive and negative comments. In short, many organizations’ activities seem more focused on “making noise” about their company and products, and less on understanding and participating in the conversations already going on about them on the Web.

7p mebachano 01-02-2013 44 5   Download