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Acute myeloid leukaemia
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Acute myeloid leukaemia (AML) is a fatal haematopoietic malignancy and is treated with the conventional combination of cytarabine (Ara-C) and daunorubicin (Dau). The survival rate of AML patients is lower due to the cardiotoxicity of daunorubicin.
12p
vishanshan
27-06-2024
1
1
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Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) are characterised by abnormal epigenetic repression and differentiation of bone marrow haematopoietic stem cells (HSCs). Drugs that reverse epigenetic repression, such as 5-azacytidine (5-AZA), induce haematological improvement in half of treated patients.
18p
vibransone
28-03-2024
3
2
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Although anti-apoptotic proteins of the B-cell lymphoma-2 (BCL2) family have been utilized as therapeutic targets in acute myeloid leukaemia (AML), their complicated regulatory networks make individualized therapy difficult.
13p
viellison
28-03-2024
2
2
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No data on predicting the survival of AML patients based on the level of trace elements in the serum have been presented to date. The aims of this prospective cohort study were as follows: (i) to evaluate the serum Cu and Zn levels in people from Northeast China, (ii) to assess the association between the serum Cu level (SCL) and Cu to Zn ratio (SCZR) and clinical and nutrition data, and (iii) to investigate the predictive values of the SCL and SCZR in newly diagnosed de novo AML patients.
11p
vileonardodavinci
23-12-2023
5
2
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For patients with acute myeloid leukaemia (AML), the only potentially curative treatment is intensive chemotherapy (IC). This is highly toxic, particularly for patients>60 years, potentially leading to prolonged hospitalisations requiring intensive supportive care, and sometimes treatment-related death. This also results in extensive healthcare costs and negatively impacts quality of life (QoL).
13p
vileonardodavinci
23-12-2023
3
3
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The presence of mixed-lineage leukaemia rearrangement (MLL-r) in paediatric patients with acute myeloid leukaemia (AML) is a poor prognostic predictor. Whether allogeneic haematopoietic stem cell transplantation (allo-HSCT) is beneficial in such cases remains unclear.
11p
vialfrednobel
23-12-2023
7
3
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Published epidemiological studies of haematological cancers are few. Hereby we present a 20-year epidemiological data of haematological cancers in Sarawak from a population-based cancer registry.
17p
visharma
20-10-2023
4
2
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Part 1 book "The genetic basis of haematological cancers" includes content: Molecular genetics of paediatric acute myeloid leukaemia, acute lymphoblastic leukaemia, the genetics of mature B-cell malignancies, the genetics of chronic myelogenous leukaemia.
180p
oursky01
24-07-2023
8
3
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Part 1 book "The genetic basis of haematological cancers" includes content: The myelodysplastic syndromes, molecular genetics of the myeloproliferative neoplasms, acute myeloid leukaemia.
218p
oursky01
24-07-2023
2
2
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Acute promyelocytic leukaemia (APL) is a unique subtype of acute myeloid leukaemia (AML) characterized by haematopoietic failure caused by the accumulation of abnormal promyelocytic cells in bone marrow (BM).
11p
viangelamerkel
27-07-2022
4
1
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Recent years, survival rates of human with high-risk acute myeloid leukaemia (AML) have not raised substantially. This research aimed to investigate the role of 4′-O-Methylbroussochalcone B, for the treatment of human AML.
13p
vianrose2711
27-04-2021
8
2
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Mutations in the FMS-like tyrosine kinase 3 (FLT3) are associated with uncontrolled cellular functions that contribute to the development of acute myeloid leukaemia (AML). We performed computer simulations of the FLT3-dependent signalling network in order to study the pathways that are involved in AML development and resistance to targeted therapies.
13p
viconnecticut2711
28-10-2020
11
0
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Deregulation of the MAPK genes signalling caused by somatic mutations have been implied in leukaemia pathogenesis, including RAS mutation (RASmut) in acute myeloid leukaemia (AML), which has been associated with intra-uterine chemical exposures.
11p
virose2711
25-09-2020
14
1
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Acute myeloid leukaemia (AML) with central nervous system (CNS) involvement in adults is uncommon, and studies of this subject are scant. Methods: We conducted a retrospective study to investigate the clinical aspects, cytogenetic abnormalities, molecular gene mutations and outcomes of adult AML patients with CNS involvement. Three hundred and ninety-five patients with newly diagnosed AML were reviewed.
10p
vialabama2711
21-09-2020
10
1
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Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to have poor-risk cytogenetics, leading to poor response and prognosis. More than one-half of all older (≥65 years) patients in the phase 3 AZA-AML-001 trial had newly diagnosed AML-MRC.
13p
vimanama2711
30-07-2020
12
2
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MicroRNAs (miRNAs or miRs) are small molecules known to be involved in post-transcriptional gene expression. Many of them have been shown to influence risk for various diseases.
6p
vibaku2711
22-07-2020
10
1
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Definite prognostic clinical factors of benefit for decitabine-based induction chemotherapy in elderly patients newly diagnosed with acute myeloid leukaemia (AML) are not identified.
10p
viputrajaya2711
22-06-2020
14
0
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No study has evaluated C-reactive protein (CRP) and plasma albumin (PA) levels longitudinally in patients with acute myeloid leukaemia (AML).
13p
vijakarta2711
09-06-2020
10
0
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(BQ) Part 2 of the document Control of biomedical systems in modelling optimization has contents: An integrated platform for the study of leukaemia, in silico acute myeloid leukaemia, in vitro studies - acute myeloid leukaemia,... and other contents. Invite you to consult the details.
150p
thuongdanguyetan10
09-03-2019
19
2
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EVI1 is a nuclear zinc finger protein essential to normal development, which participates in acute myeloid leukaemia progression and transforms Rat1 fibroblasts. In this study we show that enforced expression of Evi1 in Rat1 fibroblasts protects from paclitaxel-induced apoptosis, consistent with previously published studies.
12p
mobifone23
18-01-2013
29
2
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