Computer simulations of the signalling network in FLT3+-acute myeloid leukaemia – indications for an optimal dosage of inhibitors against FLT3 and CDK6

Mutations in the FMS-like tyrosine kinase 3 (FLT3) are associated with uncontrolled cellular functions that contribute to the development of acute myeloid leukaemia (AML). We performed computer simulations of the FLT3-dependent signalling network in order to study the pathways that are involved in AML development and resistance to targeted therapies.