Adaptive genomics
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Soft tissue sarcomas (STS), have significant inter- and intra-tumoral heterogeneity, with poor response to standard neoadjuvant radiotherapy (RT). Achieving a favorable pathologic response (FPR≥95%) from RT is associated with improved patient outcome.
16p vishanshan 27-06-2024 1 1 Download
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In ebook "Yeast protocols (Third edition)" the first eight chapters describe some basic protocols in yeast culture and genomic manipulation. Chapters 9–12 describe protocols that study certain organelles such as mitochondria and peroxisomes, and their functions in autophagy. Chapters 13– 19 are dedicated to some assays commonly used in yeast-based studies. These protocols can be potentially adapted to other organisms. The last two chapters describe two commonly used yeast-based protocols that are used to study not only yeast genes but also genes and gene products from other organisms.
325p dongmelo 27-05-2024 4 2 Download
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Severe infections with highly virulent community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are a global problem. However, the molecular events defining the evolution of CA-MRSA are still poorly understood.
14p vibransone 28-03-2024 3 2 Download
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Recent studies have used genome-wide data to investigate evolutionary mechanisms related to behavioral phenotypes, identifying widespread signals of positive selection. Here, we conducted a genome-wide investigation to study whether the molecular mechanisms involved in these traits were affected by local adaptation.
12p vibransone 28-03-2024 2 2 Download
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Mutation acquisition is a major mechanism of bacterial antibiotic resistance that remains insufficiently characterised. Here we present RM-seq, a new amplicon-based deep sequencing workflow based on a molecular barcoding technique adapted from Low Error Amplicon sequencing (LEA-seq).
15p vibransone 28-03-2024 7 2 Download
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Large-scale genomic studies of within-host diversity in Staphylococcus aureus bacteraemia (SAB) are needed to understanding bacterial adaptation underlying persistence and thus refining the role of genomics in management of SAB.
17p vibransone 28-03-2024 6 2 Download
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Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells. Using recent advances in immune repertoire sequencing technologies, models of the immune receptor rearrangement process.
14p vibransone 28-03-2024 2 1 Download
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The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response. The pathway is indispensable for the development of secretory cells by facilitating protein folding and enhancing secretory capacity.
19p vibransone 28-03-2024 5 2 Download
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Measures of the adaptive immune response have prognostic and predictive associations in melanoma and other cancer types. Specifically, intratumoral T cell density and function have considerable prognostic and predictive value in skin cutaneous melanoma (SKCM).
11p vibransone 28-03-2024 2 2 Download
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Next-generation sequencing is increasingly being used to monitor current and historic events related to the emergence and spread of antimicrobial resistance. In a recent publication, researchers analyzed the rise of methicillin-resistant Staphylococcus aureus in the 1960s, emphasizing that adaptations conferring antibiotic resistance might pre-date the introduction of novel antibiotic derivatives.
3p vioraclene 31-03-2024 6 2 Download
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Vaccines dramatically affect an individual’s adaptive immune system and thus provide an excellent means to study human immunity. Upon vaccination, the B cells that express antibodies (Abs) that happen to bind the vaccine are stimulated to proliferate and undergo mutagenesis at their Ab locus.
18p vioraclene 31-03-2024 6 2 Download
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The adaptive immune response in rheumatoid arthritis (RA) is influenced by an interaction between host genetics and environment, particularly the host microbiome. Association of the gut microbiota with various diseases has been reported, though the specific components of the microbiota that affect the host response leading to disease remain unknown.
14p vioraclene 31-03-2024 1 1 Download
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The hospital-adapted A1 group of Enterococcus faecium remains an organism of significant concern in the context of drug-resistant hospital-associated infections. How this pathogen evolves and disseminates remains poorly understood.
12p vibransone 28-03-2024 4 2 Download
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T and B cell receptor (TCR, BCR) repertoires constitute the foundation of adaptive immunity. Adaptive immune receptor repertoire sequencing (AIRR-seq) is a common approach to study immune system dynamics. Understanding the genetic factors influencing the composition and dynamics of these repertoires is of major scientific and clinical importance.
19p vibransone 28-03-2024 3 2 Download
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T-cells play a crucial role in the adaptive immune system by triggering responses against cancer cells and pathogens, while maintaining tolerance against self-antigens, which has sparked interest in the development of various T-cell-focused immunotherapies.
24p vicwell 29-02-2024 3 1 Download
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Ebook "Salt stress in plants: Signalling, omics and adaptations" will shed light on the effect of salt stress on plants development, proteomics, genomics, genetic engineering, and plant adaptations, among other topics. The book will cover around 25 chapters with contributors from all over the world. The interactions of salts with mineral nutrition may result in nutrient imbalances and deficiencies. The consequence of all these can ultimately lead to plant death as a result of growth arrest and molecular damage.
517p manmanthanhla0201 26-02-2024 5 1 Download
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Ebook "Stress signaling in plants: Genomics and proteomics perspective (Volume 1)" provides in-depth explanation of what we currently know of a particular aspect of stress signaling and where we are headed. All authors have currently agreed and abstracts have been complied for the first volume, due out midway through 2012. We aim to have the second volume out at the beginning of 2013.
240p manmanthanhla0201 26-02-2024 3 1 Download
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Ebook "Evolutionary biology: Biodiversification from genotype to phenotype" presents 20 selected contributions to the 18th Evolutionary Biology Meeting, which took place in September 2014 in Marseille. The aims of these annual meetings in Marseille are to bring together leading evolutionary biologists and other scientists who employ evolutionary biology concepts, e.g. for medical research, and to promote the exchange of ideas and encourage interdisciplinary collaborations.
406p manmanthanhla0201 26-02-2024 2 1 Download
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Ebook "Advances in the understanding of biological sciences using next generation sequencing (NGS) approaches" provides a global view of the recent advances in the biological sciences and the adaption of the pathogen to the host plants revealed using NGS. Molecular Omic’s is now a major driving force to learn the adaption genetics and a great challenge to the scientific community, which can be resolved through the application of the NGS technologies.
248p manmanthanhla0201 26-02-2024 5 2 Download
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Ebook "The science of algal fuels: Phycology, geology, biophotonics, genomics and nanotechnology" contains 26 chapters dealing with biofuels contributed by experts from numerous countries and covers several aspects of algal products, one being “oilgae from algae,” mainly oils and fuels for engines. Among the prominent algal groups that participate in this process are the diatoms and green algae (Chlorophyceae).
517p nhanphanguyet 28-01-2024 8 2 Download