Adenomatous polyp

Villous adenoma is the one subtype of adenomatous polyp that is very uncommon in the stomach. Data regarding clinical characteristics, natural history, and prognosis were scarce. This report presented an 87-year-old Thai woman with a large gastric villous adenoma incidentally revealed in a computed tomography of chest for the evaluation of right pleural effusion.

5p vidoctorstrange 06-05-2023 3 2   Download

The prevalence of gastrointestinal (GI) neoplastic polyps in Jack Russell terriers (JRTs) has increased in Japan since the late 2000s. Recently, we demonstrated that JRTs with GI polyps harbor identical germline variant in the APC gene (c.[462_463delinsTT]) in the heterozygous state. Thus, this disease is an autosomal dominant hereditary disorder.

9p vidarwin 23-02-2022 13 1   Download

Colorectal cancer (CRC) is the third most common cancer, worldwide. Recently, much attention has been given to the association between Dietary Approaches to Stop Hypertension (DASH) and CRC, however, data on colorectal adenomas (CRAs) as its precursor are scarce. Thus, the purpose of this case-control study was to investigate the association of DASH score with the risk of CRC and CRA in Iranian adults.

9p vimahuateng 26-11-2021 7 0   Download

Familial adenomatous polyposis is an inherited genetic disease, characterized by colorectal polyps. It is caused by inactivating mutations in the Adenomatous polyposis coli (Apc) gene. Mice carrying a nonsense mutation in the Apc gene at R850, which is designated ApcMin/+ (Multiple intestinal neoplasia), develop intestinal adenomas.

18p vijeeni2711 24-07-2021 15 0   Download

Little is known about colorectal adenoma patients’ ability to adhere to behavioural interventions promoting a change in diet and physical activity. This review aimed to examine health behaviour intervention programmes promoting change in diet and/or physical activity in adenoma patients and characterise interventions to which this patient group are most likely to adhere.

13p viamsterdam 18-09-2020 11 0   Download

Most cases of colorectal cancer (CRC) are initiated by inactivation mutations in the APC gene, which is a negative regulator of the Wnt-β-catenin pathway. Patients with familial adenomatous polyposis (FAP) inherit a germline mutation in one APC allele, and loss of the second allele leads to the development of polyps that will turn malignant if not removed.

13p vimale2711 25-08-2020 11 2   Download

In a large number of patients with multiple gastrointestinal adenomatous polyps, no causal germline mutation can be found. Non-genetic factors may contribute to the development of adenomatous polyps in these unexplained polyposis patients.

6p vimale2711 25-08-2020 7 1   Download

Mean platelet volume (MPV) is a marker of platelet activation. MPV and platelet count (PC) are negatively correlated, and their ratio (MPV/PC) is informative for the diagnosis of malignant tumors. However, the relationship between MPV/PC and colorectal cancer is unclear.

7p viputrajaya2711 22-06-2020 12 0   Download

Hội chứng Gardner là bệnh di truyền trội do đột biến gen trên nhiễm sắc thể thường với nhiều polyp ở đại trực tràng, u xương và bất thường răng miệng. Nguyên nhân gây ra hội chứng Gardner là do đột biến dòng mầm gen APC (adenomatous polyposis coli gene). Các đột biến trên gen APC chủ yếu là các đột biến điểm làm cắt ngắn, gây mất chức năng protein APC.

6p viaphrodite2711 14-10-2019 32 2   Download

Hội chứng đa polyp tuyến gia đình (Familial adenomatous polyposis-FAP) là bệnh di truyền do đột biến gen APC và MUTYH. Hầu hết các đột biến này là đột biến điểm nên giải trình tự là phương pháp hiệu quả nhất để phát hiện đột biến trên gen APC và MUTYH. Mục tiêu: Ứng dụng kỹ thuật giải trình tự và MLPA xác định đột biến gen APC và MUTYH gây bệnh FAP.

8p viachilles2711 10-10-2019 76 0   Download

Bệnh đa polyp tuyến gia đình (Familial adenomatous polyposis – FAP) là bệnh di truyền trội với biểu hiện lâm sàng là sự xuất hiện của hàng trăm đến hàng ngàn polyp trong đại trực tràng. Nếu không được điều trị thì 100% bệnh nhân sẽ bị ung thư đại trực tràng vào năm 35-40 tuổi. Nguyên nhân gây ra bệnh FAP là đột biến trên gen APC. Hiện nay, kĩ thuật MLPA là kĩ thuật có nhiều ưu điểm trong chẩn đoán các dạng đột biến mất đoạn gen.

6p vihermes2711 03-10-2019 80 1   Download

Hội chứng đa polyp tuyến gia đình (Familial adenomatous polyposis-FAP) là bệnh di truyền đặc trưng bởi sự hiện diện rất nhiều polyp tuyến ở đại tràng, thường trên 100 polyp. Ứng dụng kỹ thuật giải trình tự xác định các SNP ở gen APC trên bệnh nhân FAP.

5p vihephaestus2711 25-09-2019 8 0   Download

Cancer is the second leading cause of death among women. Ideally, it is desirable to prevent or at least to detect cancer in the precancerous stage. Early detection is possible by using Papanicolaou’s (Pap) test for cervical cancer, biopsies for endometrial cancer, and mammography for breast cancer. History plays a more major role in the detection of colorectal cancer, because having first-degree relatives with colon cancer; a history of colorectal, breast, endometrial, or ovarian cancer; and a history of adenomatous polyps or ulcerative colitis are identified risk factors....

165p hyperion75 21-01-2013 41 5   Download

People with MEN1 have a very high risk of developing tumors of 3 glands: the pituitary, parathyroid, and pancreas. About one-third to one-half of people with this condition also develop adrenal adenomas or enlarged adrenal glands. These usually do not cause any symptoms. This syndrome is caused by defects in a gene called MEN1. People who have a family history of MEN1 or pituitary, parathyroid, pancreas, or adrenal cancers should ask their doctor if they might benefit from genetic counseling.

53p khongmuonnghe 07-01-2013 44 2   Download

Table 87-5 Hereditable (Autosomal Dominant) Gastrointestinal Polyposis Syndromes Syndrom e Distribu Histolo nant Malig Associated Lesions tion of Polyps gic Type Potential Familial adenomatous polyposis Large intestine a Adenom on Comm None Gardner's Large Adenom Comm Osteomas, syndrome and intestines small a on fibromas, lipomas, epidermoid cysts, ampullary cancers, congenital hypertrophy retinal of pigment epithelium Turcot's syndrome Large intestine a Adenom on Comm tumors Brain Nonpoly Large Adenom on Comm al Endometri and ovarian posis syndrome int...

5p konheokonmummim 03-12-2010 102 4   Download

Several additional etiologic factors have been associated with gastric carcinoma. Gastric ulcers and adenomatous polyps have occasionally been linked, but data on a cause-and-effect relationship are unconvincing. The inadequate clinical distinction between benign gastric ulcers and small ulcerating carcinomas may, in part, account for this presumed association. The presence of extreme hypertrophy of gastric rugal folds (i.e.

6p konheokonmummim 03-12-2010 74 3   Download