Advance generation population

Major advances in genotyping technology have generated high-density maps of single nucleotide polymorphism (SNP) markers that provide an unprecedented opportunity to identify genes underlying complex traits. Several family-based statistical methods showing robust population stratification have been developed to test the association between multiple markers and disease-susceptibility genes.

6p vinarcissa 21-03-2023 2 1   Download

Multi-parent populations (MPPs) are important resources for studying plant genetic architecture and detecting quantitative trait loci (QTLs). In MPPs, the QTL effects can show various levels of allelic diversity, which can be an important factor influencing the detection of QTLs.

12p vihagrid 30-01-2023 11 3   Download

Multi-parent advanced generation intercross (MAGIC) populations are a newly established tool to dissect quantitative traits. We developed the high resolution MAGIC wheat population WM-800, consisting of 910 F4:6 lines derived from intercrossing eight recently released European winter wheat cultivars.

16p vitzuyu2711 29-09-2021 14 1   Download

Improving cotton fiber length without reducing yield is one of the major goals of cotton breeding. However, genetic improvement of cotton fiber length by breeding has been a challenge due to the narrow genetic diversity of modern cotton cultivars and negative correlations between fiber quality and yield traits.

14p vigiselle2711 30-08-2021 11 1   Download

Common bean is an important staple crop in the tropics of Africa, Asia and the Americas. Particularly smallholder farmers rely on bean as a source for calories, protein and micronutrients. Drought is a major production constraint for common bean, a situation that will be aggravated with current climate change scenarios.

20p vijeeni2711 30-06-2021 12 1   Download

Advances in next-generation sequencing technologies have provided an opportunity to perform population-level comparative genomic analysis to discover unique genomic characteristics of domesticated animals.

10p vijeeni2711 30-06-2021 14 1   Download

Hepatitis C (HCV) and many other RNA viruses exist as rapidly mutating quasi-species populations in a single infected host. High throughput characterization of full genome, within-host variants is still not possible despite advances in next generation sequencing.

12p vilichoo2711 23-06-2021 10 1   Download

Anemia is thought to affect up to 1.6 billion people worldwide. One of the major contributors to low iron (Fe) absorption is a higher proportion of cereals compared to meats and pulse crops in people’s diets.

13p vijichea2711 28-05-2021 7 1   Download

At the same time, the breeding lines from the advanced generations are also used as parental lines for developing commercially exploitable heterotic hybrids. But, most often the source of early generations i.e., F3, F4, F5 and F6 segregating populations offer wider opportunities for achieving high success, because of wider genetic base.

10p trinhthamhodang1218 26-02-2021 12 2   Download

The STriTuVaD project, funded by Horizon 2020, aims to test through a Phase IIb clinical trial one of the most advanced therapeutic vaccines against tuberculosis. As part of this initiative, we have developed a strategy for generating in silico patients consistent with target population characteristics, which can then be used in combination with in vivo data on an augmented clinical trial.

8p viwyoming2711 16-12-2020 9 0   Download

The success of most crop improvement programs depends on variability and heritability of desirable traits. An investigation was carried out during kharif 2016 at Botanical garden, University of Agricultural Sciences, Dharwad, India to assess the extent of variability generated by hybridization and to estimate the heritability and genetic advance as percent of mean for seed cotton yield and its component traits in F2 generation of cross QTP 16 × ASa 151. The segregating population thus obtained was evaluated for eight quantitative traits.

6p caygaocaolon8 07-11-2020 15 2   Download

With the advance of next generation sequencing (NGS) technologies, a large number of insertion and deletion (indel) variants have been identified in human populations. Despite much research into variant calling, it has been found that a non-negligible proportion of the identified indel variants might be false positives due to sequencing errors, artifacts caused by ambiguous alignments, and annotation errors.

10p vikentucky2711 26-11-2020 11 0   Download

Advances in single cell genomics provide a way of routinely generating transcriptomics data at the single cell level. A frequent requirement of single cell expression analysis is the identification of novel patterns of heterogeneity across single cells that might explain complex cellular states or tissue composition.

11p vioklahoma2711 19-11-2020 10 1   Download

Advances in next-generation sequencing (NGS) of antibody repertoires have led to an explosion in B cell receptor sequence data from donors with many different disease states. These data have the potential to detect patterns of immune response across populations.

10p vicolorado2711 23-10-2020 8 0   Download

An experiment was conducted on genetic variability, heritability and genetic advance in wheat population including 48 F1’s + 48 F2’s + 16 parents in RBD during Rabi 2014-15. Analysis of variance for the design of experiments revealed that mean squares due to treatments were highly significant for all the ten characters studied, while mean squares due to replications were non-significant in both F1 and F2 generations.

5p chauchaungayxua8 03-10-2020 17 2   Download

Ashwagandha (Withania somnifera (L.) Dunal) is a potent medicinal plant originated in the Indian sub continent and is used in traditional systems of medicine globally. Pure lines form an important genetic resource for improvement of yield and quality. In the present study, a set of 327 (DWS1-DWS327) pure lines were developed from JA134 out crossed population through individual plant selection, selfing and generation advancement for the first time in Ashwagandha.

17p angicungduoc6 20-07-2020 14 2   Download

In the present investigation, estimates of genetic variability, heritability and genetic advance were assessed for nine different characters in the F3 population derived from four groundnut crosses, viz., CO 7 × VRI Gn 6, TMV 2 × VRI Gn 6, TMV Gn 13 × VRI Gn 6 and VRI 2 × VRI Gn 6. Considering the mean performance, the cross derivative TMV Gn 13 × VRI Gn 6 registered superiority for the characters viz., 100-pod weight (g), 100- kernel weight (g) and sound mature kernel (%).

9p angicungduoc6 20-07-2020 11 1   Download

The first-generation epidermal growth factor receptor tyrosine kinase inhibitors gefitinib and erlotinib have both been proven effective for treating advanced non–small cell lung cancer (NSCLC), especially in East Asian patients.

14p vimanila2711 29-06-2020 8 0   Download

Plants in nature are constantly exposed to a variety of abiotic and biotic stresses which limits their growth and production. Enhancing crop yield and production to feed exponentially growing global population in a sustainable manner by reduced chemical fertilization and agrochemicals will be a big challenge. Recently, the targeted application of beneficial plant microbiome and their cocktails to counteract abiotic and biotic stress is gaining momentum and becomes an exciting frontier of research.

16p covid19 14-06-2020 28 1   Download

The objective of study was to develop high yielding (>20quintals/hectare) and high ginning out turn per cent (>35) cultures/ varieties. Out of 19 advance generation, three advance generation individual populations RS875xSA524 P12, F1861xSA668 P15, RS875xSA524 P4 had significantly higher seed cotton yield in comparison to both the check varieties H1226 (1717.37±292.3) and (F1861 1751.09 ±292.3) and possessed GOT% of 40.6, 38.5 and 39.0 and lint yield 935.6, 848.0 and772.4kg/ hectare, respectively.

9p kethamoi5 03-06-2020 13 0   Download